THERAPEUTIC APPROACH TO TREATING CLINICAL CHANGES IN POSTMENOPAUSAL WOMEN
DOI:
https://doi.org/10.31082/1728-452X-2021-225-3-20-27Keywords:
climacteric syndrome, arterial hypertension, menopause, postmenopausal period, herbal medicine, extract of rhizomes of cimicifuga (Cimicifuga racemosa)Abstract
Menopause syndrome is a pathological condition that occurs in women in the climacteric period and is characterized by neuropsychic, vegetative-vascular and metabolic-trophic disorders against the background of the extinction of reproductive functions. These changes significantly affect the overall health and quality of life of women, which requires the involvement of a multidisciplinary team of medical specialists.
Goal. Determination of the clinical efficacy of a herbal preparation containing a special standardized extract of cimicifuge rhizomes (BNO 1055) in the complex treatment of hypertension and clinical symptoms in the early postmenopausal period.
Materials and methods. Presented as the results of experimental and clinical evaluation of observation of 32 women (including those with arterial hypertension) for 12 weeks in an outpatient setting.
Results and discussion. Presents a variety of clinical changes in the postmenopausal period, considers the possibility of using alternative herbal preparations in order to reduce these symptoms and treat women with arterial hypertension in the menopause, as well as in women who categorically refuse to take menopausal sex steroids, and in patients who use menopausal hormone therapy (MHT) is absolutely contraindicated. The data on the drug extract of cimicifuga (BNO 1055), which is an alternative to MHT and at the same time effective therapy that does not have a negative effect on organs and systems, are presented.
Conclusions. The extract of rhizomes of Cimicifuga is an effective and safe phytopreparation that can be used as replacement therapy both during pre- and menopause and to improve the quality of life of women in the complex therapy of arterial hypertension.
References
Smetnik VP, Kulakov VI. Rukovodstvo po klimakteriju. M.: MIA, 2001, 120 p.
Knowledge and attitude toward menopause among women aged 40-45 years., Department of Health Education And Promotion, School of Health, Isfahan, Iran., 2013, 278 p.
Avis NE, Stellate R, Crawford S, et al. Is there a menopausal syndrome? Menopausal status and symptoms across racial /ethnic groups. Soc. Sci. Med. 2001;52(3):345-56. PMID: 11330770. doi: 10.1016/s0277-9536(00)00147-7
Nedogoda SV, Barykina IN, Khripaeva VYu, Salasyuk AS, Smirnova VO. Metabolic disorders in postmenopausal women and methods of their correction. Lekarstvennyi vestnik = Medicinal Bulletin. 2014;3(55)8:10-18 (In Russ.).
Chizhova GV, Tsvetkova TP. New approaches to the treatment of women with severe manifestations of climacteric syndrome in postmenopausal women. Dalnevostochnyi meditsinskii zhurnal = Far Eastern Medical Journal. 2010;2:48-50 (In Russ.)
Women's experience of menopause: a systematic review of qualitative evidence. University of São Paulo, The Brazilian Center for Evidence-based Healthcare: a Collaborating center of The Joanna Briggs Institute, 2015, 245 p.
Balan VE, Kulakov VI . Klimaktericheskii sindrom i fitoestrogeny [Climacteric syndrome and phytoestrogens]. Materials of the Russian conference "Pharmacy 96". M.: 2009; p.16-22
Karpovich OV, Dzugaeva I.O., Ordiyants I.M. The use of phytoestrogens in the treatment of climacteric disorders in premenopausal women. Vestnik Rossiiskogo universiteta druzhby narodov. Ser. «Meditsina» = Bulletin of the Peoples' Friendship University of Russia. Ser. "The Medicine". 2008;5:244-250. (In Russ.)
Manukhin IB, Taktarov VG, Shmeleva SV. The health of a woman in menopause. A guide for doctors. M.: Litera, 2010, p. 21-44
Rodrigo Tagle V, Mónica Acevedo, Gloria Valdés Hypertension in women. Rev Med Chile. 2013;141:237-247 http://dx.doi.org/10.4067/S0034-98872013000200014 [indexed MEDLINE / PubMed database]
Levitskaya ZI Arterial hypertension in menopausal women. Attending physician. 2006; 04/06
Wuttke V, Gorkov K, Seydlova-Wuttke D. The effect of cimicifuga (Cimicifuga racemosa) on bone metabolism, the state of the vaginal mucosa and various parameters of blood analysis in postmenopausal women: double-blind placebo-controlled and controlled by conjugated estrogens research. Russkii meditsinskii zhurnal = Russian Medical Journal. 2008;16(20):1363–1370. (In Russ.)
Zaydlova-Wuttke D, Wuttke V. A brief overview of the use of cimicifuga (Cimicifuga racemosa) in gynecology. Rossiiskii vestnik akushera-ginekologa = Russian Bulletin of Obstetrician-Gynecologist. 2009;3:47-52. (In Russ.)
Radzinsky VE, Ordiyants IM. Treatment of climacteric disorders in menopause. RMZh. Mat i ditia = RMJ. Mother and Child. 2018; 5(I):37-40. (In Russ.)
Wuttke W, Seidlová-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas. 2003 Mar 14;44 Suppl 1:S67-77. doi: 10.1016/s0378-5122(02)00350-x. PMID: 12609561.
Yureneva SV, Ermakova EI. Evaluation of the effectiveness of alternative treatments for menopausal symptoms in postmenopausal women. Ginekologiya = Gynecology. 2017;19(1):21-6. (In Russ.)
