АДАМ АҒЗАСЫНДА 23 (FGF-23) ФИБРОБЛАСТТАРДЫҢ ӨСУ ФАКТОРЫНЫҢ МӘНІ
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https://doi.org/10.31082/1728-452X-2020-217-218-7-8-37-43##semicolon##
23 фибробласттың өсу факторы##common.commaListSeparator## фосфор##common.commaListSeparator## паратгормон##common.commaListSeparator## сол жақ қарыншаның гипертрофиясы##common.commaListSeparator## сүйек - минералының бұзылуы##article.abstract##
Осы күнге дейін созылмалы бүйрек ауруы (СБА) жұқпалы емес ауруларының арасында аурушаңдығы мен өлім-жітім жағынан алдыңғы орындардың бірін алады. Ең қауіпті және клиникалық ағымы мен науқастың болжауын қиындаттыратын асқынулардың бірі- сүйек минералының бұзылуы болып табылады. 23 Фибробласттардың өсу факторы (FGF-23) - бұл фосфат алмасуын реттейтін жаңа биомаркер және СБА көптеген асқынулардың патогенезінде маңызды рөл атқарады.
Мақсаты. FGF-23 физиологиялық рөлін, сондай-ақ оның СБА прогрессиясы және оның асқынуындағы әсерін зерттеу.
Материал және әдістері. PubMed/Medine, Web of Science және Google Scholar халықаралық ғылыми мәліметтер базаларында 20 жыл бойы тереңдетілген әдеби зерттеулер ізденісі жүргізілді. Іздеу үшін келесі терминдер қолданылды: «23 фибробласттардың өсу факторы», «FGF-23», «фосфатты гомеостаз», «бүйректің созылмалы ауруы», «сүйек минералының бұзылуы», «сол жақ қарыншаның гипертрофиясы».
Нәтижелері және талқылауы. FGF-23 - бұл сүйек жасушалары бөлетін ақуыз, оның негізгі физиологиялық рөлі – сарысуда фосфордың деңгейі тұрақты болуы үшін фосфатты несеппен шығарылуын реттеу. Сонымен қатар, FGF-23 кальцитриол деңгейін төмендетеді және паратиреоид гормонының секрециясын тежейді. СБА кезінде бүйрек функциясының төмендеуіне байланысты FGF-23 деңгейінің біртіндеп өсуі байқалады, оны сарысудағы фосфор деңгейін тұрақтандыру үшін физиологиялық өтемақы деп санауға болады. Әр түрлі зерттеулерге сәйкес, FGF-23 сол жақ қарыншаның гипертрофиясы және жүрек жеткіліксіздігі сияқты жүрек-қантамырлық асқынулармен байланысты болуы мүмкін.
Қорытынды. Сонымен, FGF-23 тек СБА-да сүйек минералды бұзылыстарының маркері ғана емес, екіншілік гиперпаратиреоз бен кардиоваскулярлық асқынуларда негізгі бөлігі екен. Соны ескере отырып, FGF-23 көп салалы терапиялық нысана болып, СБА науқастардың өмірін жақсартудың болжауына әсер етеді.
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